UFC 281: Adesanya vs. Pereira was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on November 12, 2022, at the Madison Square Garden in New York City, New York, United States. A UFC Middleweight Championship bout between current champion Israel Adesanya and former Glory Middleweight and Light Heavyweight Champion Alex Pereira headlined the event. The pairing previously met twice in kickboxing matchups. The first in April 2016 which Pereira won by unanimous decision. Their second meeting took place at Glory of Heroes 7 in March 2017, which Pereira won by third-round knockout.

• Ultimate Fighting Championship
• Alex Pereira
• Israel Adesanya
• Zhang Weili
• Carla Esparza
• Dustin Poirier
• Michael Chandler
• Chris Gutiérrez
• Frankie Edgar