Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.

• Walt Disney Pictures
• Seven Bucks Productions
• Dwayne Johnson
• Emily Blunt
• Edgar Ramírez
• Jack Whitehall
• Jesse Plemons
• Paul Giamatti
• Veronica Falcón
• Dani Rovira