UFC Fight Night 126: Cowboy vs. Medeiros was a mixed martial arts event produced by the Ultimate Fighting Championship that was held on February 18, 2018, at Frank Erwin Center in Austin, Texas, United States. A welterweight bout between former UFC Lightweight Championship challenger Donald Cerrone and Yancy Medeiros served as the event headliner.

• Zuffa
• Donald Cerrone
• Yancy Medeiros
• Derrick Lewis
• Marcin Tybura
• James Vick
• Francisco Trinaldo
• Curtis Millender
• Thiago Alves