When emergencies occur, the trauma team from San Francisco City Hospital is first on the scene, traveling by land, by sea or by air to reach their victims in time. From the heights of the city's Transamerica Pyramid to the depths of the San Francisco Bay, these heroes must face the most extreme conditions to save lives, and give meaning to their own existence in the process.

• Cliff Curtis
• Derek Luke
• Anastasia Griffith
• Aimee Garcia
• Kevin Rankin
• Taylor Kinney
• Carl Marino
• Jamey Sheridan