The eighth and final season of Weeds premiered on July 1, 2012, and featured 13 episodes, bringing the series total to 102. It marks the return of the show's theme song, "Little Boxes". Creator Jenji Kohan revealed that cover versions of the song would be used during the opening credits and confirmed that Ben Folds and the Mountain Goats would be featured artists. Kohan also confirmed that the song would be covered in a duet by Steve Martin and series regular Kevin Nealon, who each sang and played the banjo. Series co-star Hunter Parrish also provided a cover version for the season's tenth episode. The final two episodes of the season aired back to back as a one-hour series finale, which was the series' first and only one hour show in its eight-year run.

• Mary-Louise Parker
• Justin Kirk
• Hunter Parrish
• Alexander Gould
• Kevin Nealon
• Jennifer Jason Leigh
• Ethan Kent
• Gavin Kent