In season five, the world is finally recovering from the deadly virus that decimated the population, but global political unrest still remains. Tom Chandler has retired and his former crew has scattered. Sasha Cooper, Lieutenant Danny Green, SBS WO-N Wolf Taylor and Sergeant Azima Kandie are on a covert mission in Panama. When they are wrongly blamed for an attack on the Panamanian President, the consequences for the United States are dire. The Nathan James must fight to prevent invasion by Latin America and the next world war.

• Eric Dane
• Adam Baldwin
• Charles Parnell
• Travis Van Winkle
• Christina Elmore
• Jocko Sims
• Kevin Michael Martin
• Michael Curran-Dorsano